Browsing 2.04 Theophane Venard School of Biotechnology by Author "Huebner, Frank"
Biodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imaging Waralee Watcharin; Schmithals, Christian; Pleli, Thomas; Koberle, Verena; Korkusuz, Hudayi; Huebner, Frank; Zeuzem, Stefan; Korf, Hans W.; Vogl, Thomas J.; Rittmeyer, Claudia; Terfort, Andreas; Piiper, Albrecht; Gelperina, Svetlana; Kreuter, Jorg (Elsevier, 2014)
Tumor visualization by magnetic resonance imaging (MRI) and nanoparticle-based contrast agents may improve the imaging of solid tumors such as hepatocellular carcinoma (HCC). In particular, human serum albumin (HSA) nanoparticles appear to be a suitable carrier due to their safety and feasibility of function- alization. In the present study HSA nanoparticles were conjugated with gadolinium diethylenetriamine- pentaacetic acid (Gd-DTPA) using carbodiimide chemistry. The nanoparticles had a uniform spherical shape and a diameter of 235 ± 19 nm. For ...