Show simple item record

dc.contributor.authorWaralee Watcharin
dc.contributor.authorSchmithals, Christian
dc.contributor.authorPleli, Thomas
dc.contributor.authorKoberle, Verena
dc.contributor.authorKorkusuz, Hudayi
dc.contributor.authorHuebner, Frank
dc.contributor.authorZeuzem, Stefan
dc.contributor.authorKorf, Hans W.
dc.contributor.authorVogl, Thomas J.
dc.contributor.authorRittmeyer, Claudia
dc.contributor.authorTerfort, Andreas
dc.contributor.authorPiiper, Albercht
dc.contributor.authorGelperina, Svetlana
dc.contributor.authorKreuter, Jorg
dc.date.accessioned2016-03-18T03:22:18Z
dc.date.available2016-03-18T03:22:18Z
dc.date.issued2014
dc.identifier.citationEuropean Journal of Pharmaceutics and Biopharmaceutics 87 (2014) 132–141en_US
dc.identifier.urihttp://repository.au.edu/handle/6623004553/17782
dc.description.abstractTumor visualization by magnetic resonance imaging (MRI) and nanoparticle-based contrast agents may improve the imaging of solid tumors such as hepatocellular carcinoma (HCC). In particular, human serum albumin (HSA) nanoparticles appear to be a suitable carrier due to their safety and feasibility of function- alization. In the present study HSA nanoparticles were conjugated with gadolinium diethylenetriamine- pentaacetic acid (Gd-DTPA) using carbodiimide chemistry. The nanoparticles had a uniform spherical shape and a diameter of 235 ± 19 nm. For better optical visualization in vitro and in vivo, the HSA-Gd nanoparticles were additionally labeled with rhodamine 123. As shown by confocal microscopy and flow cytometry analysis, the fluorescent nanoparticles were readily taken up by Huh-7 hepatocellular carci- noma cells. After 24 h incubation in blood serum, less than 5% of the Gd(III) was released from the par- ticles, which suggests that this nanoparticulate system may be stable in vivo and, therefore, may serve as potentially safe T1 MRI contrast agent for MRI of hepatocellular carcinoma.en_US
dc.format.extent10 pagesen_US
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.subjectHuman serum albuminen_US
dc.subjectNanoparticlesen_US
dc.subjectHuman hepatocellular carcinoma (HCC)en_US
dc.subjectMagnetic resonance imaging (MRI)en_US
dc.subjectGd-DTPAen_US
dc.subjectRhodamine 123en_US
dc.titleBiodegradable human serum albumin nanoparticles as contrast agents for the detection of hepatocellular carcinoma by magnetic resonance imagingen_US
dc.typeTexten_US
mods.genreArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record